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Additionally, clinical studies are also required to understand whether there is correlation of serum or synovial fluid butyrate levels with ferroptosis markers (e.g., GPX4, ROS) or disease severity in OA patients, and the chondroprotective efficacy of butyrate supply to beneficial bacteria by probiotics or dietary fibers

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However, its biodegradability is relatively low

doi: 10.3389/fphys.2021.751501 59 RogerioAPFontanariCBorducchi.KellerACRussoMSoaresEGet al

The predominantly alpha-helical C-terminal domain is involved with the binding of hydrophobic substrates (such as hydrophobic portions of xenobiotics)